In silico potential vaccine against hps06257 in Haemophilus parasuis serovar 5

In silico potential vaccine against hps06257 in Haemophilus parasuis serovar 5

نوع فایل :PDFتعداد صفحات :17
سال انتشار :1395
چکیده
Haemophilus parasuis is a small, pleomorphic, NAD-dependent member of the family Pasteurellaceae. This bacterium is the etiological agent of Glässer’s disease in swine, which is characterized by polyserositis and arthritis. Once a sporadic disease, it has increased in prevalence and severity in recent years with the adoption of new production technologies which has led to pigs being susceptible to this infection. However, a lack of protective cross-immunity against some strains and partial cross-protection among serotypes has been reported [4,5], pointing to the difficulty in identifying protective immunogens for a universal vaccine. Initial studies have already shown the importance of…