Identification and validation of Outer membrane protein (OMP) P6 3D structure and its topology in Haemophilus influenzae

Identification and validation of Outer membrane protein (OMP) P6 3D structure and its topology in Haemophilus influenzae

نوع فایل :PDFتعداد صفحات :18
سال انتشار :1395
چکیده
Haemophilus influenzae is a common human respiratory tract pathogen, causing disease in both children and adults. The bacterium is an important cause of otitis media, the most common reason for children to receive antibiotic therapy. Outer membrane protein P6 is a member of the class of outer membrane proteins known as peptidoglycan-associated lipoproteins. First discovered in the mid-1980s, P6 is a promising vaccine antigen that has been the subject of extensive study. P6 has several features suggesting that the protein may be an effective vaccine antigen. The gene that encodes P6 is present and the protein is expressed in all strains of H. influenzae examined thus far. The nucleotide sequence…